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Accepted Daily Intake (ADI) 696 Acenaphthene 245 Acenaphthylene 245 Acetaldehyde 60 Acetol (3-hydroxyacetone) 200 Acid-Hydrolysed Vegetable Proteins (acid-HVP) 177, 203, 539, 541, 567 Acrolein 51 acceptable daily intake (ADI) 65 acute dermal LD50 62 acute oral LD50 62 ambient air 53, 64 analysis methods 55 59 chemical and physical properties 56 emission 51, 53 Environmental Protection Agency (EPA) 51 formation 51 herbicide 51 inhalation toxicity 62 mechanisms of formation 59 62 occurrence in foods 53 55 precursors 53 toxicity 51, 62 65 use 51

3 36 11 7 1 20 4

cos x = cos (x + 2 )

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Acrylaldehyde, see Acrolein Acrylamide 10, 23, 566, 582, 698 agronomical factors 32, 33 analysis 30 brochures 39, 41 CIAA Acrylamide Toolbox 16, 31, 39, 40, see also CIAA Codex Code of Practice 41 exposure estimates 35, 37 FAO/WHO consultation 33 haemoglobin adduct 25, 39 health risks 37 39 JECFA evaluation 38 JIFSAN database 40 mechanisms of formation 26 30 occurrence in foods 24 25 polymer 23 railway tunnel accident 23 reduction in food 31 33, 41 Acrylaway 32 Acrylic acid 59, 61 Acute Reference Dose (ARfD) 585 Adiabatic heating 451 Adrenal Medulla lesions 129

Process-Induced Food Toxicants: Occurrence, Formation, Mitigation, and Health Risks, Edited by Richard H. Stadler and David R. Lineback Copyright 2009 by John Wiley & Sons, Inc.

1 2 2 2 2 1 3 2 28 30

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712 Advanced Glycation Endproducts (AGEs) 151, 215, 702 analysis 223 227 exposure 228 229 formation 218 223 health risks 229 232 historical perspective 215 218 mitigation 227 228 Agency for Toxic Substances and Disease Registry 65 AGE-RAGE interactions 230 Agmatine 323 Alcoholic beverages 140 143, 297, 373, see also Beer; Wine Aldehyde , -unsaturated 158 reactive 155, 701 Strecker, see Strecker aldehyde Alfalfa seeds 513 2-Alkylcyclobutanone 393 2-Alkylcyclobutanones 705 Allyl alcohol 196 Almonds, roasted 138 Alzheimer s disease 340, 702 Amadori compound 27, 220, 221, 511, 512, 515, see also Amadori rearrangement product Amadori compound, protein bound 221 Amadori rearrangement 218 Amadori rearrangement product (ARP) 150 151, 647 American Beverage Association 432 Ames Salmonella typhimurium mutagenesis assay 82, 88, 122, 131, 157, 288, 405 Amino acids 648 cross-linked 222, 475, 480 D-isomers 475, 482 Amino acid decarboxylase activity 324 -Aminoalanine 480 2-Amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) 77 2-Amino-1-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-2) 77 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) 78 2-Amino-3,4,8-trimethylimidazo [4,5-f]quinoxaline (4,8-DiMeIQx) 78 2-Amino-3,8-dimethylimidazo[4,5f]quinoxaline (8-MeIQx) 78

The -carboline compounds 9H-pyrido[3,4-b]indole (norharman) and 1methyl-9H-pyrido[3,4-b]indole (harman) are formed during the pyrolysis of

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Using the Barcode Font in Microsoft Excel (Spreadsheet)
Launch Microsoft Excel. Create a new Excel Spreadsheet. Key in the data "12345678" in the cell A1 as shown below. Enter the macro function in cell B1. Hit the Enter key to see the encoded barcode string "*12345678-*" Change the font in the cell containing the encoded barcode string (cell B1) to CCode39_S3.

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27 Feb 2014 ... Create barcodes in Excel . ... But are you looking to use a macro to do this? ..... I don't know Crystal Reports but as this code is written in VBA , ...

Again referring to Figure 101, the cosine function is symmetric along the x-axis such that Equation 107 Using Equation 107 we can replace all the matrix elements in Equation 106 with arguments to the cosine function that are greater than , giving Equation 108 Equation 108

1 1 1 14

tryptophan and are present at much higher amounts in tobacco condensates and cooked foods than are other pyrolytic or AIA HAAs (Fig. 2.3.1) (29). Norharman and harman are not mutagenic in S. typhimurium in the presence or absence of liver S9 fraction mixture; however, these -carbolines become mutagenic when incubated with non-mutagenic aniline or o-toluidine in the presence of S9 fraction mixture (30). The co-mutagenic effect was attributed to the formation of novel HAAs (31). The structures of these compounds have been determined as 9-(4 -aminophenyl)-9H-pyrido[3,4-b]indole (aminophenylnorharman, APNH), 9-(4 -amino-3-methyl-phenyl)-9H-pyrido [3,4-b]indole (aminomethyl-phenylnorharman, AMPNH), and 9-(4 -aminophenyl)-1-methyl-9H-pyrido[3,4-b]indole (aminophenylharman, APH); the compounds are produced by the respective reactions of norharman with aniline, norharman and o-toluidine, and harman with aniline (32). The formation of APH derivatives is proposed to occur via a P450 complex, where an ipso attack on the aniline (or toluidine) can occur by norharman or harman to produce these compounds (Fig. 2.3.3a). Human P450s 1A2 and 3A4 are the most active of the enzyme isoforms that catalyze this process (33). APNH is a liver and colon carcinogen in F344 rats (34). Moreover, APNH is present at comparable concentrations in the urine of smokers, nonsmokers, and patients

Figure 2.3.3 Endogenous formation of HAAs: (a) formation of 9-(4 -aminophenyl)1-methyl-9H-pyrido[3,4-b]indole (APH) via a P450 complex with aniline (adapted from Reference 32 with permission); (b) formation of IQ[4,5-b] by reaction of 2aminobenzaldehyde with creatinine.

receiving parenteral alimentation (35). These results suggest that APNH is a novel mutagen/carcinogen that is produced endogenously. 2-Amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]) is a weak bacterial mutagen (36, 37) and an isomer of IQ, a powerful experimental animal carcinogen (4). The amounts of IQ[4,5-b] measured in the urine of human volunteers who consumed grilled beef ranged from 15% to 135% of the ingested dose (38). Base treatment of urine at 70 C increased the amount of IQ[4,5-b] by more than 100-fold in carnivores and also in the urine of vegetarians. Moreover, IQ[4,5-b], but not IQ, 8-MeIQx, or PhIP, arose in the urine incubated for 3 h at 37 C: creatinine and 2-aminobenzaldehyde are the likely precursors of IQ[4,5-b] (Fig. 2.3.3b). These ndings suggest that IQ[4,5-b] is present in nonmeat staples, or alternatively that this HAA occurs endogenously within the urine or other biological uids.

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